CYP2A13 expressed in human bladder metabolically activates 4‐aminobiphenyl
M Nakajima, M Itoh, H Sakai, T Fukami… - … journal of cancer, 2006 - Wiley Online Library
Cigarette smoking is the predominant risk factor for bladder cancer. Aromatic amines such
as 4‐aminobiphenyl (ABP) is the major carcinogens found in tobacco smoke. Although it is
generally accepted that ABP is metabolically activated via N‐hydroxylation by CYP1A2 in
human liver, previous studies using Cyp1a2‐null mice indicated the involvement of other
enzyme (s). Here we found that CYP2A13 can metabolically activate ABP to show
genotoxicity by Umu assay. The Km and Vmax values for ABP N‐hydroxylation by …
as 4‐aminobiphenyl (ABP) is the major carcinogens found in tobacco smoke. Although it is
generally accepted that ABP is metabolically activated via N‐hydroxylation by CYP1A2 in
human liver, previous studies using Cyp1a2‐null mice indicated the involvement of other
enzyme (s). Here we found that CYP2A13 can metabolically activate ABP to show
genotoxicity by Umu assay. The Km and Vmax values for ABP N‐hydroxylation by …
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